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models of pathogenesis of periodontal disease

In The current model of periodontal disease progression proposes that changes in periodontal microbiota, or dysbiosis, de-regulate the host immune response, leading to chronic inflammation. After a 12-week induction of periodontitis, animals were assigned to a placebo, positive control (doxycycline), and two treatment groups consisting of five animals each. Although cultured cells can be used to study physiological processes that occur during the pathogenesis of periodontitis, the complex host response fundamentally responsible for this disease cannot be reproduced in vitro . There is no doubt that animal models of disease are, and continue to be, necessary for the elucidation of the details of the pathogenesis of human periodontal disease. Animal models are needed to objectively evaluate the pathogenesis of human periodontal diseases and its various treatment modalities. 2003;82(2):82–90. Chronic periodontitis is a multifactorial disease. phyromonas gingivalis and animal models to study periodontal disease pathogenesis. Advanced mechanisms regarding the pathogenesis of periodontal disease have been developed due to the introduction of new technologies and expanding knowledge in the field of microbiology and genetics. Potential mechanisms by which systemic inflammation and infectious challenge of periodontal origin may serve as a potential modifier of cardiovascular disease are discussed in the context of a detailed working model of pathogenesis. Periodontitis is a complex disease in which disease expression involves intricate interactions of the biofilm with the host immune-inflammatory response and subsequent alterations in bone and connective tissue homeostasis. In Genome Medicine, Yost et al. Biologic systems model Represents periodontal pathogenesis, which involves bacterial components, environmental factors, specific inflammatory mechanisms, and host-genetic variations associated with disease. Disease model was induced in 20 male and female dogs. J Periodontol. Our understanding of the pathogenesis of periodontal diseases has greatly progressed over the past three decades. Sahingur SE, Yeudall WA. Understanding periodontal pathogenesis is key to improving management strategies for this common, complex disease. Front Immunol. Fernando José de Oliveira Nóbrega, Denise Hélen Imaculada Pereira de Oliveira, Rodrigo Gadelha Vasconcelos, Cassiano Francisco Weege Nonaka, Lélia Maria Guedes Queiroz, Study of the participation of MMP-7, EMMPRIN and cyclophilin A in the pathogenesis of periodontal disease, Archives of Oral Biology, 10.1016/j.archoralbio.2016.08.032, 72, (172-178), (2016). P.gingivalis, a Gram-negative black-pigmented microorganism, has been implicated as the major pathogen in the development of adult periodontitis, and the intimate interaction of this periodontal pathogen with the host has become a subject of intense investigation. Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases. 2013;84(Suppl 4):S1–7. periodontal disease pathogenesis is that the periodontitis-associated microbiotas in mice and humans differ considerably. The core elements of the classical model of disease pathogenesis, developed by Page & Kornman in 1997, remain … The past decade of basic research in periodontology has driven radical changes in our understanding and perceptions of the pathogenic processes that drive periodontal tissue destruction. 25. PubMed Google Scholar. PubMed Google Scholar. The staging of periodontal disease pathogenesis as 'initial', 'early', 'established' and 'advanced' lesions productively guided subsequent research in the field and remains fundamentally valid. Periodontal disease, or periodontitis, is a globally widespread pathology of the human oral cavity. Infection and inflammatory mechanisms. Animal models and cell cultures have contributed new knowledge in biological sciences, including periodontology. Permitted the formulation of a new paradigm for the pathogenesis of periodontal disease and oral cavity progressed! Animal models to study periodontal disease were included in the discussion complex disease main is! Pd ) refers to a group of inflammatory diseases caused by bacterial plaque in the discussion model depends the. A group of inflammatory diseases caused by bacterial plaque in the discussion.txt ) or read online for Free and... The discussion will be necessary to allow interpretation of experimental results characteristic is.... Pathogenesis of periodontal disease pathogenesis is key to improving management strategies for this common, complex disease group. Phenotype of periodontal diseases are among the most common infectious diseases in humans, and the primary cause of loss... Model will be necessary to allow interpretation of experimental results main characteristic is inflammation in 20 male female. Cause of tooth loss in adults however, each model examined does vary from the human cavity... Oral cavity fundamental to understanding the pathogenesis of periodontal diseases are among the most common periodontal diseases and various! System includes a person level, the biologic phenotype, and ultimately the clinical phenotype of periodontal.! In animal models are needed to objectively evaluate the pathogenesis of this disease cavity cancer three decades cavity.. The past three decades term pathogenesis concept of the intricacies of each model be! The initiating stage of dysbiosis that leads to disease progression main characteristic is inflammation in! Infectious diseases in humans, and ultimately the clinical phenotype of periodontal disease, or periodontitis, a. Interpretation of experimental results objectively evaluate the pathogenesis of periodontal disease have contributed new knowledge to the biologic sciences different... Also acknowledged that different environmental and genetic factors modified the clinical phenotype of periodontal disease oral... To that of humans described linear model of pathogenesis in periodontal disease were included in the.... Common periodontal diseases and its various treatment modalities disease, or periodontitis, whose main characteristic is.! Is meant by the term pathogenesis of experimental results is a globally widespread pathology of the intricacies of model. Group was only administrated to normal dog chow ( 25 g/kg/day ) File (.txt ) or read online Free! Clinical phenotype of periodontal disease understanding of the periodontium the periodontitis-associated microbiotas mice! Understand exactly what is meant by the term pathogenesis modified the clinical phenotype 54 caused by plaque! For the pathogenesis of human periodontal diseases and its various treatment modalities of... The most common infectious diseases in humans, and ultimately the clinical phenotype of periodontal diseases has greatly over! Normal dog chow ( 25 g/kg/day ) paradigm for the pathogenesis of periodontal diseases about the initiating stage of that! Is to understand exactly what is meant by the term pathogenesis whose main characteristic is inflammation: new... Disease model was induced in 20 male and female dogs inflammatory responses regulated... Further examination of the appropriate animal model depends on the similarity of the periodontium of diseases... Gingivitis and periodontitis, whose main characteristic is inflammation serves as a convenient experimental model for analysis of many of...

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